The Role of Coenzyme Q10 in Cellular Bioelectricity: Bridging Bioenergetics and Bioelectric Signaling

 This is for informational purposes only. For medical advice or diagnosis, consult a professional.

Coenzyme Q10 (CoQ10) is a lipid-soluble molecule crucial for cellular energy production and maintaining the electrochemical gradient across membranes.

* Crane, F. L. (2001). Biochemistry of coenzyme Q. Journal of Bioenergetics and Biomembranes, 33(1-2), 247-259.

In the electron transport chain (ETC) within mitochondria, CoQ10, in its reduced form (ubiquinol), accepts electrons from complexes I and II.

* Ernster, L., & Dallner, G. (1995). Biochemical, biophysical and clinical aspects of ubiquinone function in mitochondria and submitochondrial particles. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1271(1), 195-204.

This electron transfer drives the pumping of protons across the inner mitochondrial membrane, establishing the proton motive force.

* Mitchell, P. (1961). Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Nature, 191(4784), 144-148.

* Mitchell, P. (1976). Vectorial chemistry and the molecular mechanics of chemiosmotic coupling: power coupling of transmembrane proton movements to energization of metabolic and membrane transport processes. Annals of the New York Academy of Sciences, 264(1), 185-216.

This proton gradient powers ATP synthesis via ATP synthase.

* Boyer, P. D. (1997). The ATP synthase – a splendid molecular machine. Annual Review of Biochemistry, 66(1), 717-749.

By cycling between oxidized (ubiquinone) and reduced (ubiquinol) forms, CoQ10 maintains the ionic balance across the mitochondrial membrane, essential for both energy production and cellular homeostasis.

* Turunen, M., Olsson, J., & Lankinen, E. (2004). Coenzyme Q10: biological aspects and clinical applications. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1660(1-2), 171-199.

The mitochondrial membrane potential, driven by the ETC, is crucial for various cellular functions, including ion transport, nutrient uptake, and neurotransmitter release.

* Nicholls, D. G., & Ferguson, S. J. (2013). Bioenergetics 4. Academic Press.

Connecting CoQ10 to Bioelectricity:

Dr. Michael Levin's research emphasizes the role of bioelectric signals, generated by ion flows and voltage gradients, in various biological processes.

* Levin, M. (2014). Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo. Current Biology, 24(17), R766-R774.

* Levin, M., et al. (2019). Bioelectric signaling: a key regulator of regeneration, development, and cancer. Trends in Biotechnology, 37(1), 72-87.

CoQ10's role in maintaining ionic gradients supports the electrochemical conditions necessary for cellular bioelectric communication.

* Murphy, M. P., & Smith, R. A. (2007). Targeting antioxidants to mitochondria: a therapeutic strategy for neurodegenerative diseases. Annual Review of Pharmacology and Toxicology, 47(1), 629-656.

While direct experimental evidence linking CoQ10 to specific bioelectric signaling pathways may be limited, its crucial role in mitochondrial function and maintaining cellular energy homeostasis suggests a potential indirect influence on bioelectric phenomena.

* Schon, E. A., Przedborski, S., & Wolf, N. I. (2010). Mitochondria: generators of cellular bioenergetics, mediators of apoptosis, and movers of cell death. Cell Metabolism, 11(3), 157-165.

 


 

Here's what I'm taking:
Puritan's Pride Coenzyme CoQ10 100mg, Dietary Supplement for Heart Health, Blood Pressure, Oral Gum Health, and Healthy Aging Support, 60 Day Supply, 240 Rapid Release Softgels

1 Body Thyroid Support Supplement with Iodine, Vitamin B12, Zinc, 60-Day Supply, 2 Pack

Heart Support and Blood Pressure Supplement, 120 Capsules, Promotes Cardiovascular Health, Healthy Cholesterol, Triglyceride, Homocysteine, CRP Levels | Natural Artery Cleanse and Protect  

I formulated what I think would be the ultimate supplement for Ionic health, but the cost for a small batch run was about $17/bottle of 30. Ouch. This looks pretty close:

Liquid Ionic Multi Mineral Supplement (32oz) Doctor Formulated. - Unflavored - Zero Calories. Zero Sugar. Keto Friendly. by Eniva Health.

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